Marie Scott, 57, was last seen at around 12pm on Monday 18 December 2017 on Sandileigh Avenue, Hale.
Despite extensive enquiries by officers, we have unfortunately been able to find her so far.
She is described as 5ft 4ins tall with mid-length blonde hair.
Officers know she boarded a 12.30pm train at Altrincham station the same day she went missing and got off at Deansgate in the city centre at 12.54pm.
From there she has made her way along Deansgate to outside Blacks where she spoke to a couple at about 1.07pm.
There has then been a further sighting reported of Marie at the Duke Street Car Park just before 2:10pm.
Detectives have now released CCTV images of the moment Marie spoke with the couple in the hope of identifying and speaking to them.
Detective Sergeant Dave Jones from Stretford CID said: “I want to stress the man and woman pictured are not in any trouble at all.
“It might be that Marie asked you for directions or you had a really general conversation – whatever it was we could really do with knowing anything that might lead us to her.
“So if this is you and you remember stopping to speak to a woman on Deansgate that day, please contact us immediately.
“It’s been nearly two weeks since Marie went missing and without her using her card or phone, we are trawling through CCTV piecing together her steps.
“Her family are understandably beside themselves and it is vital that we find her.
“We know she went to Castlefield shortly after Deansgate and again, if anyone saw Marie or spoke to her then please contact us.
“Please look at the images of her we have issued and try and remember if you have seen her.”
Anyone with information about Marie’s whereabouts is asked to contact police on 101 quoting MP/17/0111851. Reports can also be made anonymously through the independent charity Crimestoppers on 0800 555 111.